Temporal Evidence Attribution in Patient Narrative Reconstruction from Fragmented EHR Events
Abstract
The widespread adoption of electronic health records has resulted in an unprecedented accumulation of clinical data. However, this data is often highly fragmented, distributed across unstructured clinical notes, structured laboratory results, prescription records, and radiological reports. Clinicians face significant cognitive burdens when attempting to synthesize these disjointed events into a coherent patient history. Recent advancements in natural language generation have proposed automated patient narrative reconstruction to alleviate this burden. Despite these advances, existing models often suffer from a lack of interpretability and fail to accurately attribute generated narrative sentences to their originating source events, a critical requirement for clinical safety. This paper addresses this gap by introducing a comprehensive framework for temporal evidence attribution in patient narrative reconstruction. By mapping fragmented clinical events into a temporally aware dependency graph, the proposed methodology explicitly links generated narrative segments to their underlying source data points. The study provides an extensive analysis of current methodologies, details a novel architecture for semantic and temporal alignment, and evaluates the framework against robust baseline models. The findings demonstrate significant improvements in both narrative coherence and clinical verifiability. This research contributes to the broader domain of medical informatics by providing a foundation for transparent, evidence-based automated clinical summarization, ultimately supporting safer and more efficient clinical decision-making.Keywords
Electronic Health Records, Narrative Reconstruction, Temporal Reasoning, Evidence Attribution, Clinical Informatics
References
- 1. Chen, Z., Gao, P., Lee, Y., Barthelemy, J., Zhou, L., & Wang, L. (2025, June). Optimizing Efficiency and Visual-Textual Alignment for LLM-Based Radiology Report Generation. In 2025 IEEE International Conference on Multimedia and Expo (ICME) (pp. 1-6). IEEE.
- 2. Zhang, W., Luo, Z., Gu, C., Ma, J., Cao, Y., Yuan, W., & Jin, Y. (2025). Bridging the compression-precision paradox: A hybrid architecture for clinical EEG report generation with guaranteed measurement accuracy. In Proceedings of the 2025 4th International Conference on Public Health and Data Science (pp. 201–207).
- 3. Xia, X., Wang, X., Li, Q., Li, N., & Li, J. (2013). Essential amino acid enriched high-protein enteral nutrition modulates insulin-like growth factor-1 system function in a rat model of trauma-hemorrhagic shock. PLoS One, 8(10), e77823.
- 4. Hu, Y., Huang, Z. A., Liu, R., Xue, X., Sun, X., Song, L., & Tan, K. C. (2023). Source free semi-supervised transfer learning for diagnosis of mental disorders on fMRI scans.IEEE Transactions on Pattern Analysis and Machine Intelligence,45(11), 13778-13795.
- 5. Sha, L., Wang, Y., Meng, P., Deng, Y., Chen, T., Zhang, X., ... & Xu, Q. (2025). Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures. Nature Chemical Biology, 21(11), 1742-1753.
- 6. Zhao, K., Li, G., Li, C., Jiang, T., Wang, W., & Yang, Z. (2026). Identification Markers for Salvia miltiorrhiza and Its Close Relatives Based on Cell Wall Component Characteristics. Engineered Science, 40, 2122.
- 7. Gao, X. L., & Wang, M. (2026). Enhancing cancer immunotherapy antibody discovery: Genetic algorithms and risk-aware protein modeling. Available at SSRN 6033537.
- 8. Lyu, M., Torii, R., Liang, C., Zhang, X., Wang, X., Li, Q., ... & Chen, D. (2025). Predictive computational framework to provide a digital twin for personalized cardiovascular medicine. Communications Medicine, 5(1), 370.
- 9. Lyu, M., Torii, R., Liang, C., Li, Q., Wang, X., Ventikos, Y., & Chen, D. (2025). In silico comparison of two non-invasive pre-procedural virtual coronary revascularisation techniques for personalised cardiovascular medicine. Computer Methods and Programs in Biomedicine, 109046.
- 10. Yu, X., Zhang, Y., & Wang, H. (2025, July). Subjective Sleep Gains in Empty Nose Syndrome: A Cautionary Note on the Need for Objective Validation. In International Forum of Allergy & Rhinology (Vol. 15, No. 7, pp. 761-762).
- 11. Verhoven, Bret, et al. "Attenuating Ischemia and Reperfusion Injury Using NAD+-Loaded Nanoparticles in Mouse Kidneys." Transplantation Direct 12.1 (2025): e1890.
- 12. Yin, Li, et al. "Targeted NAD+ Delivery for intimal Hyperplasia and Re-endothelialization: a novel anti-restenotic therapy approach." bioRxiv (2024): 2024-02.
- 13. Sinha, D., Tong, Y., Zepeda, M. A. F., Hanstad, G., Nelson, E. C., Theisen, C. O., ... & Gamm, D. M. (2023). Silica nanocapsules as a nonviral delivery platform for iPSC-RPE.Investigative Ophthalmology & Visual Science,64(8), 774-774.
- 14. Kabra, Meha, et al. "Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy." The Journal of Clinical Investigation 133.19 (2023).
- 15. Xia, F., Li, B., An, B., Zachman, M. J., Xie, X., Liu, Y., ... & Cheng, Y. (2024). Cooperative Atomically Dispersed Fe–N4 and Sn–N x Moieties for Durable and More Active Oxygen Electroreduction in Fuel Cells. Journal of the American Chemical Society, 146(49), 33569-33578.
- 16. Wang, Y. (2025, August). AI-AugETM: An AI-augmented exposure–toxicity joint modeling framework for personalized dose optimization in early-phase clinical trials. In 2025 19th International Conference on Complex Medical Engineering (CME) (pp. 182-186). IEEE.
- 17. Wu, Y., Wei, J., Wang, S., & Rus, V. (2026, May). Persona-Conditioned Generation of Patient Self-Reports from EHRs. In Proceedings of the Fifteenth Language Resources and Evaluation Conference (LREC 2026) (Vol. 11, No. 16, pp. 10792-10801).
- 18. Huang, Y., He, W., Zhao, M., McClements, D. J., Xu, Y., Li, L., ... & Li, C. (2025). Unraveling the health contributions of five key bioactives in virgin olive oil: A dose-based comparative review. Trends in Food Science & Technology, 105274.
- 19. Ma, H., Dai, X., Wang, T., He, Z., Du, R., Pei, H.,... & Zhao, K. (2025). Investigation of uridine in anti-aging-related diseases based on network pharmacology, molecular docking and cell experimental validation. Engineered Science, 35, 1572.
- 20. Yang, Z., Guo, D., Fu, Y., Qi, L., Zhu, T., Ma, X.,... & Zhao, K. (2025). Investigating the Fracture Treatment Mechanism of Dipsacus asper Based on Network Pharmacology, Molecular Docking and Molecular Dynamics Simulation. Engineered Science, 38, 1856.
- 21. Xi, Y., Zhao, Z., Zhou, Y., Yin, C., Li, Y., Xu, X.,... & Shen, W. (2026). Macrophage efferocytosis mediated by the TP63-RAC2 pathway promotes immunosuppressive remodeling in esophageal cancer. Cell Reports Medicine, 7 (1).
- 22. Sun, X., Hu, X., Wei, J., & An, H. (2025). Uncovering leading compounds for alzheimer’s disease treatment: mendelian randomization and virtual screening insights into plasma protein modulation. Biological Research, 58.
- 23. Sun, Z., Xu, Y., Liu, Y., Tao, X., Zhou, P., Feng, H., ... & Liu, Z. (2025). Associations of Exposure to 56 Serum Trace Elements with the Prevalence and Severity of Acute Myocardial Infarction: Omics, Mixture, and Mediation Analysis: Sun et al. Biological Trace Element Research, 203(9), 4466-4478.
- 24. Leung, P. H., Wang, F., Li, Z., He, Z., Peng, Y., & Yang, W. F. (2026). Augmented Reality Integration Improves Ergonomics in Dynamic Navigation for Dental Implant Surgery. Journal of the Society for Information Display, 34(5), 428-435.
- 25. Chai, L., Li, H., Zhao, X., Cui, C., Zheng, B., Zhang, K., ... & Jiang, L. (2023). Analysis of altered flowering related genes in a multi-silique rapeseed (Brassica napus L.) line zws-ms based on combination of genome, transcriptome and proteome Data. Plants, 12(13), 2429.
- 26. Lian, X., Wang, Y., Guo, J., Wan, X., Ye, X., Zhou, J.,... & Li, J. (2024). The short-term effects of individual and mixed ambient air pollutants on suicide mortality: A case-crossover study. Journal of hazardous materials, 472, 134505.
- 27. Chai, L., Wang, J. M., Fan, Z., Liu, Z. B., Li, X., & Yang, Y. (2011). Ascorbate peroxidase gene from Brassica napus enhances salt and drought tolerances in Arabidopsis thaliana. African Journal of Biotechnology, 10(79), 18085-18091.
- 28. Thompson, J. D., Higgins, D. G., & Gibson, T. J. (1994). CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Research, 22(22), 4673–4680.
- 29. Poplin, R., Chang, P.-C., Alexander, D., Schwartz, S., Colthurst, T., Ku, A., et al. (2018). A universal SNP and small-indel variant caller using deep neural networks. Nature Biotechnology, 36(10), 983–987.
- 30. Rajkomar, A., Oren, E., Chen, K., Dai, A. M., Hajaj, N., Hardt, M., et al. (2018). Scalable and accurate deep learning with electronic health records. NPJ Digital Medicine, 1, 18.
- 31. Gulshan, V., Peng, L., Coram, M., Stumpe, M. C., Wu, D., Narayanaswamy, A., et al. (2016). Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA, 316(22), 2402–2410.
- 32. Sievers, F., Wilm, A., Dineen, D., Gibson, T. J., Karplus, K., Li, W., et al. (2011). Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Molecular Systems Biology, 7, 539.
- 33. Eraslan, G., Avsec, Ž., Gagneur, J., & Theis, F. J. (2019). Single-cell transcriptomics meets deep learning. Nature Methods, 16(11), 1083–1091.
- 34. Avsec, Ž., Agarwal, V., Visentin, D., Ledsam, J. R., Grabska-Barwińska, A., Taylor, K. R., et al. (2021). Effective gene expression prediction from sequence by integrating long-range interactions. Nature Methods, 18(10), 1196–1203.
- 35. Cao, X., Tao, J., Liu, Z., Lyu, R., & Li, J. (2026). Handling Missing Data in CALL: A Data Quality-Driven Imputation Framework for Learner Analytics. Future-Adaptive Intelligence and Lifelong Systems, 1 (1).
- 36. Zhu, R., Jiang, B., Mei, L., Yang, F., Wang, L., Gao, H., ... & Zhang, D. (2025). Adaptflow: Adaptive workflow optimization via meta-learning. arXiv preprint arXiv:2508.08053.
- 37. Breiman, L. (2001). Random forests. Machine Learning, 45(1), 5–32.